Jornal de Microbiologia Alimentar e Industrial

Synthesis, Whole-cell Biotransformation and Evaluation of the Antibacterial and Antifungal Activity of Chalcone-derived Lactones

Abstract

Noah Brown

Chalcone-derived lactones have garnered significant attention for their diverse pharmacological properties, including antibacterial and antifungal activities. In this study, we present a comprehensive synthesis of novel chalcone-derived lactones and employ whole-cell biotransformation techniques to enhance their bioavailability. The antibacterial and antifungal potential of these transformed compounds is evaluated against a panel of clinically relevant pathogens. Our findings reveal promising antimicrobial activity, highlighting the potential of chalcone-derived lactones as a valuable class of compounds for the development of novel therapeutics.