Jornal de Biomarcadores Moleculares e Diagnóstico

Urinary Neutrophil Gelatinase Associated Lipocalin and Interleukin-18 as Early Predictors of Kidney Injury in Neonates

Abstract

Mohamed S El Frargy and Neama A Soliman

Background: Early detection of renal affection in neonates is vital for early treatment and prevention of dangerous complications, so the using of some markers like urinary neutrophil gelatinase associated lipocalin (uNGAL), interleukin-18 (uIL-18) is very important as the commonly used detectors as creatinine are very late.

Patient and methods: This study included 80 neonates and was carried out at neonatal intensive care unit (NICU), pediatrics department, Tanta university hospital, Egypt from 6/2013 to 6/2015. Group 1 (kidney injury-patient group): This group included forty neonates Group 2 (Control Group): This group included forty healthy neonates from outpatient clinic. uNGAL, uIL-18 and serum creatinine were assessed in 80 neonates at day 1 and day 3 of neonatal intensive care unit admission who had renal affection later proved by BUN serum creatinine.

Results: Means of uNGAL, uIL-18 and serum creatinine in the day 1 of admission in cases and control groups were (30.94 ± 10.05 vs 6.7 ± 4.49), (11.61 ± 9.00 vs 1.1.98 ± 1.18) and (0.64 ± 0.17 vs 0.59 ± 0.19) respectively with p-value <0.05 which was significant in uNGAL and uIL-18 only.

Conclusions: uNGAL and uIL-18 are considered simple and accurate markers in early detection of renal impairment in neonates which are better than serum creatinine