Jornal de Biomarcadores Moleculares e Diagnóstico

The Declaration of a Multi-Biomarker Panel as the Key to Ovarian Cancer Diagnosis

Abstract

Eric Boruah*

Early detection of ovarian cancer has been difficult in order to manage the high mortality rate caused by this deadly disease. The scientific contributions from around the world have helped to reduce mortality trends, but it remains the fifth leading cause of gynaecological mortality. The complexities in the clinical presentation, tumour origin, and gene expression profiles had added to the difficulty in understanding and diagnosing the disease. A stage 1 diagnosis of ovarian cancer increases the 5-year survival rate to around 92%. Cancer antigen-125 is the gold standard tumour marker found in abnormally high levels in the blood of many women with ovarian cancer. However, many non-cancerous conditions have high CA-125 levels, and several women have normal CA-125 levels in the early stages of ovarian cancer.