Jornal de Biomarcadores Moleculares e Diagnóstico

Mean Platelet Volume is a Promising Diagnostic Marker For Systemic Inflammation in Cirrhotic Patients with Ascitic Fluid Infection

Abstract

Abdelmoez Amal, Atalla Mahmoud, Hefny Zeinab, Abdellatif Zeinab, Adel Eman, Abbas Bahaa, Mehrez Mai, Guda Mohamed, Abouelkhair Mahmoud and Elzahry Mohammad AME

Introduction: Spontaneous bacterial peritonitis (SBP) is the most frequent and life-threatening infection in patients with decompensated liver cirrhosis. Diagnosis should be prompt and treatment must not be delayed until the microbiology results are available.

Aims and Methods: The current study was conducted to assess the potential role that MPV may have in the diagnosis of SBP in cirrhotic patients with ascites Three groups were included in the study. Group I (SBP group) included 100 patients with liver cirrhosis and ascites complicated by SBP, group II (non-SBP group) included 98 patients with liver cirrhosis and ascites without SBP and group III included 50 healthy subjects to serve as a control group.

Results: ESR, CRP and total leucocytic count (TLC) in ascitic fluid were significantly higher in SBP group compared to non-SBP group (median 37.5 vs. 12, 12 vs. 5 and 530 vs. 60 respectively with p value<0.01). The MPV was significantly higher in SBP group vs. non-SBP group and healthy control group (8.5, 7.9 and 8.3 respectively and P value<0.0001). On constructing ROC curve for the MPV; at a cutoff value of 8.4 fl, MPV had 73% sensitivity and 85.7% specificity for detecting SBP with overall accuracy 79.3%, (AUC=0.84 with negative predictive value (NPV) and positive predictive value (PPV) for MPV of 75.7 and 83.9%, respectively). Regarding ESR; at a cutoff value of 20.

Conclusion: MPV is increased in SBP in cirrhotic patients with ascites than the other inflammatory markers.