Jornal de Biomarcadores Moleculares e Diagnóstico

A Systematic Review of the Proteomics Approach for Biomarkers and Periodontitis Diagnosis

Abstract

Yuniarti Soeroso*

We wanted to see how accurate salivary matrix metalloproteinases (MMP)-8 and -9, as well as tissue inhibitor of metalloproteinase (TIMP)-1, were at diagnosing periodontitis and differentiating periodontitis stages 1 to S3. This was a case-control study involving patients with periodontitis S1 to S3 and healthy periodontia. Saliva was collected, and clinical parameters such as plaque index, bleeding on probing, probing pocket depth, and clinical attachment level were recorded. Radiography was used to confirm the diagnosis by measuring the alveolar bone level. An enzyme-linked immunosorbent assay was used to measure salivary biomarkers. A total of 45 patients and 18 healthy subjects served as controls.