Journal of Nephrology & Therapeutics

Profile of Cross match positive Reports among pretransplant Patients at Shahid Dharma Bhakta National Transplant Centre, Nepal

Abstract

Archana Bagale*

Introduction: The presence of donor-specific antibodies (DSAs) against HLA molecules is a risk factor for humoral rejection after kidney transplantation. The introduction of the complement-dependent cytotoxicity (CDC) test has been a major step forward in excluding high-risk donoracceptor combinations.

Objective: To find out profile of positive Cross match Reports among pretransplant patients.

Design: Case series design.

Settings: Shahid Dharma Bhakta National Transplant Centre, Bhaktapur.

Subjects : Patient who had positive cross match reports from Oct 16, 2021 to May 13, 2022.

Method: List of patients prepared who are being prepared for renal transplant Process in duration of six months. There were 46 such pair prepared for transplant and with positive cross match reportsEnumerative sampling technique was used for data collection.

Results: The current study depicits that there is significant statistical association between PRAI and DSAII report of pretransplant pair. i.e, (P: 0.002). There is strong statistical association between CDC and PRAII report of pretransplant pair. (p:0.000). There is statistical association between DSA I and COVID 19 infection of pretransplant pair. (p:0.033). There is statistical association between DSA II and COVID infection report of pretransplant pair. (p:0.008).

Conclusion: Introduction: The presence of donor-specific antibodies (DSAs) against HLA molecules is a risk factor for humoral rejection after kidney transplantation. The introduction of the complement-dependent cytotoxicity (CDC) test has been a major step forward in excluding high-risk donor-acceptor combinations.