Jornal de Genética e Pesquisa de DNA

Inhibition of hyaluronan for the treatment of pulmonary hypertension

Abstract

Harry Karmouty Quintana

Pulmonary hypertension (PH) is a highly lethal and widespread lung disorder that is a common complication in chronic lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). Its presence in these chronic lung diseases is the single most significant predictor of mortality. While increased levels of hyaluronan have been observed in IPF patients, hyaluronan-mediated vascular remodeling and the hyaluronan-mediated mechanisms promoting PH associated with IPF are not fully understood.