Hepatology and Pancreatic Science

Incidence Risk Factors and Outcomes of Acute Liver Injury in Hospitalized Adults with Acute Kidney Injury: A Large Multicentre Study

Abstract

Kiara Patrick*

Acute liver injury and acute kidney injury are critical conditions often seen in hospitalized patients, each associated with significant morbidity and mortality. The intersection of these two conditions can compound patient outcomes, presenting a complex clinical challenge. This article explores the incidence, risk factors, and outcomes of ALI in patients with AKI, based on data from a large multicenter study. ALI is characterized by a sudden increase in liver enzymes, indicating liver cell damage. AKI involves a rapid decline in kidney function, leading to the accumulation of waste products in the body. Both conditions can arise from various etiologies, including drug toxicity, infections, ischemia, and underlying chronic diseases. The interplay between liver and kidney functions, often referred to as the hepatorenal axis, suggests that dysfunction in one organ can significantly impact the other.