Jornal de Genética e Pesquisa de DNA

Genomic Instability and Cancer: Mechanisms and Therapeutic Implications

Abstract

Diego Fernandez*

Genomic instability is a hallmark of cancer, driving tumorigenesis and tumor evolution. Understanding the mechanisms underlying genomic instability is crucial for developing effective cancer therapies. This mini-review explores the various causes of genomic instability, including DNA damage, replication errors and impaired DNA repair mechanisms. We discuss the implications of genomic instability for cancer development, progression and therapeutic resistance. Furthermore, we highlight emerging therapeutic strategies targeting genomic instability pathways for cancer treatment.