Medicina Molecular e Genética

Gastric Cancer: Is Era of Molecular Classification Here?

Abstract

Xuchen Zhang and Antonio Galvao Neto

Gastric cancer has a dismal prognosis and remains one of the deadly diseases worldwide. It has increasingly been recognized that gastric cancer is heterogeneous disease, which may be subdivided into different groups based on histological, anatomical, and molecular classifications. New classifications combining histological features,anatomical locations, and molecular signatures will help improve our understanding of the biology and pathogenesis, and aid in finding novel therapeutic targets in gastric cancers.