Genética Humana e Embriologia

Dependence between Breast Cancer in Women and Body Mass Index. The Role of L-Carnitine in Prediction and Outcomes of the Disease

Abstract

Hojouj Mohammad I. M., Chabanova K. N., I. N. Bondarenko, Viktor Zavizion and Hojouj Tamar*

The incidence of breast cancer in the world in general and in Ukraine in particular is growing. In 2017, in Ukraine the incidence reached 16 percent of female population. According to the Ministry of Health in Ukraine 26% of the female population for 2017 was overweight or obese. There is a strong biologic basis for an association of obesity with poor breast cancer outcomes. Obesity-a chronic metabolic character, which is the result of the interaction of the endogenous factors, environmental conditions and lifestyle. Endogenous factors could be considered a violation of the genetic and hormonal balance. The external conditions include irregular rhythm nutrition, use of substandard products. By disorders include sedentary lifestyle lifestyles. Obesity is the first risk factor for metabolic syndrome, diabetes type II, cardiovascular disease and some forms of cancer, including breast cancer. Since overweight is a risk factor for breast cancer, there is reason to believe that among patients with breast cancer the percentage of obese women is higher than in the population. The risk of breast cancer in postmenopausal women is more by 30% in premenopausal, women with obesity 50%. Furthermore it was proven that obesity is associated with poor prognosis in patients with breast cancer, regardless of menopausal status.