Jornal de Microbiologia e Patologia

Deciphering the Pathological Basis of Autoinflammatory Diseases

Abstract

Moraes Krueger

Autoinflammatory diseases represent a group of disorders characterized by dysregulated immune responses leading to recurrent episodes of inflammation without an identifiable external trigger. These conditions pose significant challenges in diagnosis and management due to their heterogeneous nature and overlapping clinical features with other inflammatory disorders. Recent advances in immunology, genetics and molecular biology have shed light on the underlying pathological mechanisms driving autoinflammatory diseases, unveiling novel therapeutic targets and diagnostic strategies. This article provides an overview of the current understanding of the pathological basis of autoinflammatory diseases, highlighting the key molecular pathways involved and the implications for clinical practice.