Revista de Farmacognosia e Produtos Naturais

Cytotoxic Xanthone from the Stem-Bark of Anthocleista vogelii (Planch)

Abstract

Olukayode Solomon Ajayi, Olaoye Solomon Balogun and Folasade Agnes Ajinuhi

In this study, the crude, defatted extracts and the pure isolated xanthone (1,8-dihydroxy-2,5-dimethoxyxanthone) were screened in vitro for cytotoxicity activities, the xanthone was isolated from the defatted fraction of the aqueous methanolic stem-bark extract. The cytotoxic activity was evaluated using the brine shrimp lethality test of stem bark extract and the isolated compound, 1,8-dihydroxy-2,5-dimethoxyxanthone gave LC50 values less than 200 μg/mL, indicating a high pharmacological potential and could serve as anticancer agent.