Medicina Molecular e Genética

Colon Cancer and Immunotherapy: CD40 Ligand as a Potential Therapeutic Target

Abstract

Orfanos S, Patelis N, Davakis S, Vailas M, Damaskos C, Margonis GA, Pikoulis E and Antoniou E

CD40, a member of the tumor necrosis factor (TNF) superfamily, it is broadly expressed on a variety of cells. There are studies to suggest that the expression of CD40 is correlated to several malignancies, while its innate therapeutic qualities are yet to be confirmed. Colon cancer is one of the most common cancers, while little can be done for the patients with advance colon cancer even at the presence time. CD40 are present in the colon cancer, and are a possible therapeutic immunotherapy target in order to enhance the overall survival rates of the patients with advanced disease.