Medicina Molecular e Genética

Cancer: Stress and PAI-1

Abstract

Lasierra-Cirujeda J, Aza-Pascual-Salcedo MJ, Aza-Pascual-Salcedo MM, Lasierra-Ibañez A and Lasala-Aza C

Cancer is a group of diseases that are characterized by the development of abnormal cells, which divide almost without limit, develop, spread without control anywhere in the body, losing the cells their ability to disappear by an anti- apoptotic action, essential process for malignant transformation and tumor development. The onset and development of cancer is associated with multiple causes and predisposing factors such as stress and psychosocial factors PAI-1 is a gene regulated by stress and is paradoxicallyinteracted in close relation with uPA in the development of tumors.