Aynias Seid* and Nega Berhane
Abstract Genetic engineering is a thoughtful modification process of animal’s genome using recombinant DNA technology for generating transgenic animals. Transgenic animals are genetically altered animals having the desired traits. Genetically engineered animals have a significant medical application for human healthcare by making the transgenic animal models of human disease for studying of gene function; manufacturing of transplant organs; and production of safe and complex recombinant human protein-based drug, blood and vaccine products with higher expression and low cost for the treatment and prevention of human disease. The first two commercially accessible therapeutic agents isolated from the milk of transgenic animals are C1 esterase inhibitor (Ruconest®) and Antithrombin III (ATryn®), which encourages that a novel recombinant protein will be created and become available for practical use in the near future. So that, transgenic animals will provide a pharmacological revolution for discovery and development of drugs, clinical trials of xenotransplant human organs or xenotransplantation that will be the unchoice option to diminish the growing gap between demand and severe shortage of appropriate organs for recipient human patients with serious organ failure.
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