Metabolômica: Acesso Aberto

High Serum Concentration of Sulfatide is a Risk Factor for Restenosis in Patients with Coronary Heart Disease after Percutaneous Coronary Intervention

Abstract

Li G, Hu R, Wu HZ and Chen SX

Objective: Restenosis after Percutaneous Coronary Intervention (PCI) is regarded as the result of a combination of various pathological events. The mechanisms are complex and not completely understood. This study aims to determine the correlation between the concentration of serum sulfatide and restenosis after PCI.
Method: We studied 68 consecutive patients with CHD of single-vessel disease who successfully underwent PCI. All patients were evaluated by a follow-up angiography approximately 6.5 months after the PCI and were divided into two groups, the restenosis (20 patients) and the nonrestenosis (48 patients). We measured and compared serum sulfatide levels and conventional cardiovascular risk
factors in those two groups.
Result: The serum sulfatide concentration (18.73 ± 3.81 μmol/L) in the restenosis group was significantly higher than that (11.52 ± 3.37 μmol/L) in the nonrestenosis group (p<0.01). Multiple logistic regression analysis for risk factors revealed a significant correlation between serum sulfatide and restenosis after PCI (p<0.05). The concentration of serum sulfatide was positively correlated with the
coronary percent stenosis at the time of follow-up angiography (r=0.32, p<0.05).
Conclusion: High concentration of serum sulfatide is therefore a risk factor for restenosis after PCI in patients with CHD.