Revista de Bioprocessamento e Biotécnicas

Glucose Metabolism Control

Abstract

Henggui Zhang

Cultured mammalian cells are the primary source of biologics. Cellular metabolism has a significant impact on the performance of these cell culture processes in terms of both productivity and product quality attributes. The primary carbon source for cellular biosynthesis and energy generation is glucose. Recent advances in our understanding of the regulation of glucose metabolism in cultured cells are summarised here. Allosteric regulation of the metabolic network, interplay between signalling pathways, and transcription factors enable cells to maintain homeostatic states in widely varying environments. Understanding metabolism regulation holds the key to changing the metabolic regulatory circuit and implementing direct metabolic control over cell culture processes.