Revista de Bioprocessamento e Biotécnicas

Determination of Clopidogrel Bisulphate in Plavix Tablet and Human Biological Fluids Utilizing Chemically Modified Carbon Paste Sensor

Abstract

Amal Fouad Khorshid*

The fabrication and the performance response characteristics of a novel sensitive, selective, simple, and rapid sensor for the determination of Clopidogrel bisulphate (CLO-H₂SO₄) were described. The sensing modified carbon paste sensor comprised of an ion-pair based on Clopidogrel with silico tungastate (CLO-ST) where this study included: composition, usable pH range, response time and temperature. The sensorex hibiteda wide linear dynamic concentration ranging from 1.00x10−7-1.00x10−2 and the usable pH ranges from 1.2-4.8 with the response time ranging from (5-8 sec) which is much faster compared to liquid ISEs with a detection limit equals 0.34 nM. The selectivity of the sensor (CLOH₂SO₄) was applied with respect to a many of organic and inorganic cations, amino acids and sugars. The application of the sensor (CLO-H₂SO₄) for its determination was utilized in bulk powder, Plavix Tablet, human (serum-urine) and monitoring Plavix tablet dissolution rates using calibration curve, standard addition, and the potentiometric titration methods. The obtained results were statistically analyzed in both accuracy and precision and were compared using the US pharmacopeia method where there is no significant difference was observed.