Jornal de Citologia e Histologia

Thyroid malignancy presents a significant challenge in diagnosis due to its diverse histological presentations and the potential for overlapping features with benign lesions. Cytological examination plays a pivotal role in the initial assessment of thyroid nodules, guiding subsequent management decisions. This article provides an in-depth exploration of cytological insights into thyroid malignancy, highlighting diagnostic strategies to enhance accuracy and optimize patient care.

This comprehensive review delves into the intricate relationship between clinic-pathological features and immunohistochemical analysis. By synthesizing current research, it illuminates how immunohistochemistry enables a deeper understanding of disease processes, aiding in diagnosis, prognosis and therapeutic decision-making. From cancer to autoimmune disorders, the review navigates the diverse applications of this analytical tool, shedding light on its pivotal role in advancing clinical practice and enhancing patient care.

DNA methylation, an epigenetic modification crucial for gene regulation, exhibits remarkable heterogeneity across different tissues, developmental stages and individuals. This mosaic-like pattern of methylation plays a pivotal role in cellular identity, differentiation and disease susceptibility. Understanding the intricacies of this heterogeneity offers insights into fundamental biological processes and opens avenues for therapeutic interventions. This review delves into recent advancements in elucidating the complex landscape of DNA methylation mosaic, highlighting its implications in health and disease.

Neurosurgical intraoperative histology techniques have significantly advanced in recent years, providing surgeons with real-time diagnostic information during surgical procedures. This abstract provides an overview of various techniques employed in intraoperative histology, including frozen section analysis, touch imprint cytology and rapid immunohistochemistry. These methods enable rapid pathological assessment of tissue samples, aiding in surgical decision-making and improving patient outcomes. Furthermore, emerging technologies such as stimulated Raman scattering microscopy and confocal microscopy offer high-resolution imaging capabilities, enhancing intraoperative tissue visualization. This abstract highlights the clinical relevance and utility of these techniques in guiding neurosurgical interventions, reducing operative time and minimizing the need for subsequent reoperations.

Type 3 transformation zones present unique challenges in cervical cytology interpretation due to their dynamic nature and potential for discrepancies in sampling. This article explores the clinical significance of negative cytology results within Type 3 transformation zones, highlighting diagnostic considerations and implications for patient management. Through a comprehensive review of current literature and clinical insights, we aim to elucidate the complexities of interpreting negative cytology in Type 3 transformation zones and provide guidance for healthcare professionals in optimizing cervical cancer screening strategies.

Cellular topography, the spatial distribution of cells within tissues, plays a crucial role in understanding tissue function and pathology. This article delves into the intricate cyto- and histopographic patterns of CPA3-positive cells, shedding light on their significance in various physiological and pathological contexts. CPA3, carboxypeptidase A3, serves as a marker for a distinct subset of cells with diverse functions in immunity, inflammation and tissue homeostasis. By elucidating the distribution of CPA3-positive cells across different tissues, this research provides valuable insights into their roles in health and disease.