Jornal de Citologia e Histologia

Plasmacytoma is a localized collection of malignant plasma cells. The disease is divided into Solitary plasmacytoma of the bone (SPB) and extramedullary plasmacytoma (EMP) which are both distinct entity. SPB usually occur in the bones characteristically affected in multiple myeloma and EMP was most frequently located in the oronasopharynx and paranasal sinuses, with a 15-30% incidence of regional lymph node involvement. We report a case of Solitary plasmacytoma of medial end clavicle resulting in pain and swelling of left clavicle in a 28 year old farmer. SPB can involve any bone in the body but involvement of medial end of clavicle though reported is a very rare presentation.

Fibroblasts have been shown to possess the capacity to differentiate into follicular dendritic cells in lymph nodes and into myofibroblasts in wounded tissues. Here, we demonstrate that foreskin-derived fibroblasts also have the potential to differentiate into adipocytes and osteoblasts under cell culture, developed for the differentiation of bone marrow derived mesenchymal stem cells (BM-MSC).