Jornal de Anestesiologia e Pesquisa da Dor

Therapeutic Potential of Targeting the PERK Signaling Pathway in Ischemic Stroke

Abstract

Jamie Chlond

Ischemic stroke is a leading cause of mortality and long-term disability worldwide. Despite significant advancements in stroke management, effective therapeutic strategies remain limited. Emerging evidence suggests that the PERK (protein kinase RNA-like endoplasmic reticulum kinase) signaling pathway plays a pivotal role in the pathophysiology of ischemic stroke. This article explores the molecular mechanisms underlying PERK activation during ischemic insult and discusses the therapeutic potential of targeting this pathway in stroke management.