Biologia Molecular: Acesso Aberto

The Effect of Malva neglecta on the Reduction of Inflammatory Agents in Patients with Osteoarthritis

Abstract

S Maryam Mirghiasi , Mohadese Akhzari, Mahnesa Vassaf, Atiye Akbari and S Mahshid Mousavi Baghi

Osteoarthritis is a common joint disease in old ages. The current therapies are not often effective, since those are associated with some side effects such as peptic ulcers and gastrointestinal bleeding. Because of the degree of inflammation associated with pain in the patients with osteoarthritis, research on the plants with anti-inflammatory properties, although low, in addition to the analgesic effects, can make a substantial contribution to the patients with osteoarthritis, because the side effects caused by steroidal and non-steroidal anti-inflammatory drugs (NSAIDs) are not induced by them.

In this study, we investigated the medicinal plants of Iran and found the role of Malva (Malva neglecta) in reducing bone-joint symptoms, therefore, the plant was investigated to determine the most effective dose and to study whether the clinical effects is associated with anti-inflammatory effect. Due to the role of chondrocytes and monocyte/ macrophage cells on the process of inflammation in the osteoarthritis, our study was performed on these two cell lines, as a model similar to what occurs in the human osteoarthritis.