Jornal Internacional de Neurorreabilitação

The Effect of Erythropoietin on Total Protein Levels during Ischemia Reperfusion Injury in Rats

Abstract

Τsompos C*, Panoulis C, Τοutouzas K, Ζografos G and Papalois A

Aim: The aim of this experimental study was to examine the effect of erythropoietin on rat model and particularly in an ischemia-reperfusion (IR) protocol. The beneficial effect or non-effectiveness of that molecule was studied biochemically using blood mean total protein levels.

Materials and Methods: 40 rats of mean weight 247.7 g were used in the study. Total protein levels were measured at 60 min (groups A and C) and 120 min (groups B and D) of reperfusion. Erythropoietin was administered in groups C and D.

Results: Epo administration non-significantly decreased the predicted TP levels by 1.27% ± 1.51% (p=0.3721). Reperfusion time non-significantly increased the predicted TP levels by 1.27% +1.51% (p=0.3549). However, erythropoietin administration and reperfusion time together produced a non-significant combined effect in decreasing the predicted TP levels by 0.68% ± 2.48% (p=0.4430).

Conclusions: Erythropoietin administration interacted or not with reperfusion time has non-significant short – term decreasing effects on blood total protein levels.