Jornal Internacional de Neurorreabilitação

Participate in the Pathophysiology of Neurological Diseases

Abstract

Gunce Basarir*

Extracellular vesicles have emerged as a novel communication paradigm of the complement system in neurological diseases. Complement is an essential part of the innate immune system, playing a crucial role in host defense, tissue homeostasis, and immune regulation. However, dysregulation of the complement system has been implicated in the pathogenesis of various neurological disorders, including Alzheimer's disease, multiple sclerosis, and stroke. In recent years, it has become evident that complement components are present in EVs, which are small membranous vesicles secreted by cells into the extracellular space. These EV-associated complement proteins and microRNAs can modulate immune responses, contribute to neuroinflammation, and participate in the pathophysiology of neurological diseases. This article explores the role of EVs as a means of complement communication in neurological diseases and highlights their potential as diagnostic biomarkers and therapeutic targets.