Microbiologia Médica e Diagnóstico

Occurrence of Multidrug Resistance Escherichia coli and Other Bacteria Species Associated with Urinary Tract Infection in Two Geopolitical Zones of Ondo State, Nigeria

Abstract

Ogunyemi TM, Timothy Olubisi Adejumo, Olajubu FA and Titilayo Modupe Waire

Urinary tract infection (UTI) is a common bacterial infection known to affect different parts of the urinary tract of both male and female. Escherichia coli have been found to be responsible for causing 80% to 90% of the infection. An investigation was carried out to determine the prevalence of bacteria, especially E. coli implicated in UTI, and to ascertain their antibiotics susceptibility pattern. Early morning mid-stream urine samples were collected from 250 patients aged 18 to 60 years, between March and July of 2016 from 5 major Hospitals in the study location. The isolates were identified using standard microbiological methods and susceptibility tests were carried out using ten antibiotics. Results Showed that 65 (30.7%) of the isolates were E. coli. Pseudomonas aeruginosa 45 (21.2%), Klebsiella pneumoniae 42 (19.8%), Staphylococcus aureus 32 (15.1%) and Proteus mirabilis 28 (13.2%). The percentages of resistance of E. coli isolates to antimicrobial agents were chloramphenicol (64.9%), sparfloxacin (59.5%), ciprofloxacin (73.0%), septrin (73.0%), amoxacillin (91.9%), augmentin (83.8%), gentamycin (48.7%), perfloxacin (40.5%), ofloxacin (40.5%) and streptomycin (54.1%). The need for constant antimicrobial susceptibility surveillance by health managements system that will help clinicians to provide safe and effective therapy is advocated.