Jornal Internacional de Neurorreabilitação

Novel Approaches to Peripheral Nerve Repair

Abstract

Chanla Tink

Peripheral Nerve Injuries (PNIs) represent a significant clinical challenge, often resulting in debilitating sensory, motor, and autonomic dysfunction. Traditional approaches to nerve repair have been limited in their ability to fully restore function, prompting the exploration of novel strategies within the realm of regenerative medicine. In this review, we delve into the latest advancements in peripheral nerve repair, focusing on innovative approaches that hold promise for revolutionizing the field. Before delving into novel approaches, it's crucial to grasp the intricate processes involved in nerve regeneration. Following injury, the peripheral nervous system exhibits a remarkable capacity for self-repair, orchestrated by a cascade of cellular and molecular events. Schwann cells, the principal glial cells of the peripheral nervous system, play a central role in promoting axonal regeneration through the secretion of growth factors and formation of regeneration-supportive microenvironments. However, the extent and efficacy of regeneration are often compromised by various factors, including the severity and type of injury.