Pesquisas e Relatórios em Ciências Médicas

Meta-analysis of Metformin Absorption and Pharmacokinetics in Nine Species

Abstract

Saeed Razvi

Meta-analysis is a powerful tool for synthesizing data across multiple studies to provide a comprehensive understanding of a particular topic. In this study, we conducted a meta-analysis of metformin absorption and pharmacokinetics across nine different species. Metformin is a widely prescribed drug for the management of type 2 diabetes mellitus, but its pharmacokinetics can vary significantly between species, influencing its efficacy and safety profile. By systematically reviewing and analyzing data from published studies, we aimed to elucidate species-specific differences in metformin absorption and pharmacokinetics. Our findings reveal notable variations in metformin absorption rates, distribution volumes and elimination half-lives among different species. These differences have important implications for translational research and drug development, highlighting the need for species-specific dosing regimens and pharmacokinetic modeling approaches to optimize metformin therapy across diverse patient populations.