Jornal de Citologia e Histologia

Histopathological Changes in Neurodegenerative Diseases: Implications for Diagnosis and Therapy

Abstract

Marian Fassun*

Neurodegenerative diseases represent a significant and growing burden on global healthcare systems, affecting millions of individuals worldwide. Understanding the histopathological changes associated with these diseases is crucial for accurate diagnosis and the development of effective therapeutic strategies. This review explores the histopathological hallmarks of major neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral sclerosis. We discuss the molecular and cellular mechanisms underlying these histopathological changes, their implications for disease diagnosis, and current and emerging therapeutic approaches targeting these pathological features.