Biologia Molecular: Acesso Aberto

Endoplasmic Reticulum Stress and its Impact on Adipogenesis

Abstract

Andrea Lech

The Endoplasmic Reticulum (ER) is a vital organelle responsible for protein folding, lipid synthesis, and calcium homeostasis within the cell. Under conditions of cellular stress, such as nutrient overload or disturbances in calcium levels, the ER can become dysregulated, leading to a state known as endoplasmic reticulum stress. ER stress has been implicated in various metabolic disorders, including obesity and type 2 diabetes. One key aspect of metabolic regulation affected by ER stress is adipogenesis, the process by which precursor cells differentiate into adipocytes. This article explores the mechanisms underlying ER stress, its role in adipogenesis, and its implications for metabolic health.