Ashraf Youssef Nasr
Background: Cisplatin (CP) is one of the most effective antineoplastic drugs used for the treatment of various solid tumors. However, the nephrotoxic effect of CP limits its clinical use. The present study aimed to evaluate the possible protective effect of misoprostol (MP) against cisplatin-induced nephrotoxicity.
Material & Methods: Twenty four male rats were randomly divided into four equal groups (control, cisplatintreated, misoprostol-treated and combined misoprostol and cisplatin-treated). Group II rats were treated with CP single i.p. dose of 7.5mg/kg on 5th day. Group III Rats were treated with oral MP at a dose of 200μg/kg/day for nine days. Group IV rats were treated with single oral dose of 200μg/kg/day MP for nine consecutive days and injected with CP single i.p. dose (7.5mg/kg) on 5th day. Body weight of rats was recorded on 1st, 3rd, 5th, 7th and 9th. days. On the 10th day, the rats were anesthetized by ether and scarified. Blood samples were obtained to determine creatinine and BUN levels. Body weight, Kidney weight & body weight/kidney weight ratio were calculated. Specimens of rats’ kidneys were prepared for both light and electron microscopic examinations.
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