Imunoquímica e Imunopatologia

Determination of Anti-Inflammatory and Analgesic Activities of a Citrus Bioflavanoid, Hesperidin in Mice

Abstract

M Vabeiryureilai, K Lalrinzuali and Ganesh Chandra Jagetia

Inflammation is one of the important responses elicited by organisms to counteract obnoxious stimuli. However, continuous inflammation has been responsible for the induction of several diseases. Therefore, it is essential to combat excess inflammation by devising countermeasures to neutralize excess inflammation. The present study was undertaken to investigate the analgesic and anti-inflammatory activities of hesperidin, a citrus flavonoid in mice using standard procedures employed for these activities including hotplate, acetic acid, tail immersion, xylene and formalin-induced edema tests. Treatment of mice with different doses of hesperidin revealed that hesperidin induced analgesic and anti-inflammatory activities in a dose dependent manner as indicated by pain inhibition and reduced inflammation. The maximum effect was observed for 300 mg/kg b. wt. hesperidin. Our study demonstrates that hesperidin has analgesic as well as anti-inflammatory action.