Jornal de Trauma e Tratamento

Correlation of Circulating Matrix Metalloproteinase-3 and Osteopontin Levels with Postmenopausal Osteoporosis

Abstract

Yi DAI

Objective: To study Matrix Metalloproteinase-3 (MMP-3) and Osteopontin (OPN) levels and correlations of MMP- 3 and OPN with Bone Metabolic Markers and Bone Mineral Density (BMD) in postmenopausal Chinese women.

Methods: MMP-3, OPN Osteoprotegrin (OPG), Osteoprotegrin Ligand (OPGL) of 120 postmenopausal Chinese female volunteers was measured using ELISA. BMD were measured using dual energy X-ray absorptiometry. According to the criteria of WHO, women were divided into 3 groups, such as normal, oteopenia and osteoporosis group.

Results: OPN concentrations were significantly higher in osteoporosis (56 ± 20) ng/ml than normal (26 ± 11) ng/ml (P<0.05). But MMP-3 concentrations were little higher in osteoporosis (153 ± 121) ng/ml than normal (125 ± 101) ng/ml. In osteoporosis, notable negative correlations between OPN, ratio of OPN/MMP-3 and BMD, sOPGL were found (P<0.05) as well as positive relations between OPN, ratio of OPN/MMP-3 and sOPG (P<0.05), and positive relation of MMP-3 and BMD of Ward’s triangle was existed (P<0.05), in osteopenia negative relations of MMP-3 and BMD as well as ratio of OPN/MMP-3 were detected (P<0.05).

Conclusion: There are significant correlations between serum OPN, ratios of OPN and MMP-3 and bone biomarkers of sOPG, sOPGL, OPN and OPN/MMP-3 may increase with high bone-metabolism. The increases of OPN and ratio of OPN/MMP-3 appear possibly as a concomitant event in high bone turnover state, such as postmenopausal osteoporosis.