Jornal de Citologia e Histologia

Contrast-Enhanced Imaging Characteristics of Steatohepatitic Hepatocellular Carcinoma and Clinicopathological Investigation

Abstract

Xuhao Song*

With 906,000 newly diagnosed cases worldwide in 2020, hepatocellular carcinoma is the sixth most common malignant tumour and the third leading cause of cancer-related deaths. The prevalence of HCC varies by ethnicity, with the majority of patients suffering from chronic infections of the hepatitis B and C viruses, metabolic-dysfunction-associated fatty liver disease, or alcoholic steatohepatitis. MAFLD, formerly known as nonalcoholic fatty liver disease, is characterised histologically by hepatocyte steatosis, steatohepatitis, Mallory's body, and fibrosis. MAFLD currently affects 30% of the global population, despite the fact that only 5% of patients will progress to MAFLD-related fibrosis or HCC. Although chronic HBV infection remains a major cause of HCC in China, MAFLD-related primary liver cancer has increased.