Jornal de Citologia e Histologia

Antioxidant Modulation of Hematological Toxicity during Chemotherapy for Breast Cancer

Abstract

Hojouj Mohammad, Bondarenko I, Zavizion V, Artemnko M, Soloviova N, Bondarenko Y, Dmytrenko K and Urzhumova N

Side effects of anticancer drugs seriously limit the achievement of the maximum therapeutic effect of the most cytostatic. One of the pathophysiological bases of side effects is the ability of cytotoxic agents to intensify the freeradical processes and the consequent lipid peroxidation (LPO) in the cell membranes of various organs. When the antitumor treatment is conducted, the antioxidant enzyme deficiency increases, there is the depletion of nonenzymatic and enzymatic mechanisms of oxidation protection units, resulting in a reduction of organism resistance and damage to vital organs and systems. In this connection it is important to study the possibility of correction of violations occurring in cancer patients with drugs with antioxidant action type.