Journal of Hypertension: Open Access

Analysis of Peripheral Blood Cells Due to Adults Posthepatitic Cirrhotic Portal Hypertension and Their Postoperative Prognosis

Abstract

Yunfu Lv, XiaoYu Han, Xiaoguang Gong, Wenbiao Gu, Chao He, Hongfei Wu, YeJuan Li and Jie Den

Objectives: To explore the constituent ratio of peripheral blood cells changes in patients with splenomegaly due to posthepatitic cirrhotic portal hypertension and its postoperative prognosis, and to grade the peripheral cytopenias.

Methods: Data of 366 cases of splenomegaly due to posthepatitic cirrhotic portal hypertension were collected and analyzed.

Results: Thirty-six patients (9.8%) had a normal blood cell count and 330 patients had peripheral cytopenias, in which mono-lineage cytopenias accounted for 30% (99/330), bi-lineage cytopenias accounted for 35.8% (118/330) and tri-lineage cytopenias accounted for 34.2% (113/330). There were significant statistical differences (P<0.05) in the postoperative prognostic comparison between mono-lineage cytopenias and multi-linage cytopenias. In the 330 cases of cytopenias, the postoperative prognosis demonstrated significant differences between thrombocytopenia, leukopenia and erythropenia (P<0.05). For the most part, according to the severity of thrombocytopenia, cytopenia was graded as mild, medium and severe, and scored as <2 points, 2-3 points and >3 points, respectively. The prognosis revealed significant differences between the three grades (P<0.05).

Conclusions: Peripheral cytopenias can influence postoperative prognosis. Thrombocytopenia is a major factor influencing postoperative prognosis and grading is of great significance in analyzing the condition of inpatients and guiding their treatment.