Jornal de Trauma e Tratamento

Amantadine Effect on Neurorecovery of Patients with Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Abstract

Marian Irene Escasura

The increasing number of Traumatic Brain Injury (TBI), mostly due to accidents, greatly contributes as one of the major cause of long-term disability in the world. The brain injury causes neurological dysfunction via direct tissue disruption and delayed pathophysiological changes in the molecular and cellular level resulting to neuronal death. The pathophysiological changes seen play an important role in chronic neurodegeneration leading to neurological impairment. Reversing this pathophysiological change may help reduce significant morbidity and mortality.