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Journal of Bioengineering & Biomedical Science

2-Aminoethyl Diphenylborinate (2-APB) Analogues: Part 4 - Poly-Boron Compounds: Regulators of Ca2+ Release and Consequent Cellular Processes

Abstract

Shoichiro Ozaki*

Inhibitory activities of 74 poly-boron compounds for SOCE and IICR were measured. Activities of poly-boron compounds were compared with 2APB, mono-boron and bis-boron compounds. The IC50 of best poly-boron compound 1042 was 2 μM. This value was almost same as IC50 3 μM of 2-APB. Poly (aminoethoxyboryldiphenylether) 1042 is best candidate for regulation of Ca2+ release and consequent cellular processes in this paper.

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