Jornal de Patogênese Microbiana

Antibiotic resistance in pathogenic bacteria represents a critical threat to global public health. This comprehensive review examines the molecular mechanisms underpinning antibiotic resistance, including enzymatic degradation, target modification, efflux pumps, and biofilm formation. We also explore the genetic basis of resistance, encompassing horizontal gene transfer and mutation. By understanding these mechanisms, we aim to identify potential targets for novel therapeutic strategies and to inform policy development for antibiotic usage. The review concludes with a discussion on the implications of antibiotic resistance and future directions for research.

Pseudomonas aeruginosa is a versatile pathogen known for its ability to cause a wide range of infections, particularly in immunocompromised individuals. This review delves into the molecular mechanisms underlying its virulence, focusing on key factors such as biofilm formation, secretion systems, toxins, and antibiotic resistance. By exploring the genetic regulation and environmental triggers of these virulence factors, we aim to provide a comprehensive understanding of P. aeruginosa pathogenicity. This knowledge can inform the development of novel therapeutic strategies to combat infections caused by this formidable pathogen.

Biofilm formation by Staphylococcus aureus poses a significant challenge in clinical settings, contributing to persistent infections and antibiotic resistance. This review explores innovative strategies to prevent and disrupt biofilms, including the use of antimicrobial peptides, quorum sensing inhibitors, and novel drug delivery systems. We also examine the potential of bacteriophage therapy and the role of nanotechnology in enhancing treatment efficacy. By understanding and targeting the unique characteristics of S. aureus biofilms, these novel approaches hold promise for improving patient outcomes and reducing healthcare costs associated with chronic infections.

Inflammatory Bowel Disease (IBD), encompassing Crohn's disease and ulcerative colitis, is a chronic inflammatory condition of the gastrointestinal tract with a complex etiology involving genetic, environmental, and immunological factors. Emerging evidence highlights the significant role of gut microbiota in the pathogenesis of IBD. This review explores the mechanisms by which dysbiosis, or microbial imbalance, contributes to intestinal inflammation. We examine the interactions between gut microbes and the host immune system, the impact of microbial metabolites, and potential therapeutic strategies targeting the microbiota. Understanding the role of gut microbiota in IBD pathogenesis could pave the way for novel diagnostic and therapeutic approaches.