Jornal de Histologia Molecular e Fisiologia Médica

In human cancer, dominant oncogenes and tumor suppressor gene mutations are critical occurrences. Many molecular methods, including single-strand conformational polymorphism, polymerase chain reaction, cloning, and sequencing, are employed to detect these anomalies, however, the biological significance of these alterations is not always obvious. Immunohistochemistry (ICH) or western blotting of aberrant gene products can reveal information about their cellular localization and expression in neoplastic vs normal cells, as well as a hint regarding their function. For example, ICH has demonstrated that deletion of the intercellular adhesion molecule E-cadherin, or aberrant localization from the cell membrane to the cytoplasm, is associated with a widespread tumor phenotype and a poor clinical prognosis. 

The use of a subunit viral vaccination to prevent a specific viral infection has had little effectiveness. This is in contrast to the period when the whole Cowpox virus was used for vaccination to prevent the smallpox viral pandemic in China over a thousand years ago before Edward Jenner approved it in a scientific method despite the fact that immunity was unknown. Nowadays, a thorough understanding of immunology has been discovered. With the goal of preventing side effects, subunit viral vaccines became the most popular alternative for viral vaccine production. Many types of viral vaccinations, on the other hand, were unable to match our success. There is some debate as to why viral vaccinations aren't effective for everyone.

Chemotherapy, surgical excision with a safe margin, and radiation are all used to treat bone and soft tissue sarcomas. Although good results have been recorded in individuals with non-metastatic sarcomas, the results in patients with metastatic or recurring sarcomas are still poor. New therapies or changes of conventional treatments are needed to combat metastatic or recurring sarcomas. Recent research and reviews on therapeutic targets, anticancer drugs, immunotherapy, and care in patients with bone and soft tissue sarcomas were featured in this special issue. Several studies and reviews of aberrant gene expression in bone and soft tissue sarcomas were featured in this special issue. 

Non-small cell lung cancer (NSCLC) is responsible for roughly 27% of all cancer-related fatalities globally, making it a serious public health issue. Healing needs full, indefinitely-lasting tumor removal (usually by surgery or radiation [RT]), although substantial shrinking (typically by systemic therapies) might result in long-term disease management. More realistically, in the absence of treatments, hosttumor interactions, which are major determinants in the natural history of diseases, will have a significant impact on disease progression, with treatments primarily aimed at causing the host-tumor balance to tip toward improvement or, if possible, healing.

Professor Georg Meissner and Professor Rudolf Wagner originally characterized Meissner corpuscles in 1852. They are also known as Wagner-Meissner corpuscles or tactile corpuscles. These unique encapsulated nerve terminals are found in the dermal papillae of glabrous skin and convey delicate touch and low-frequency vibration sensations to the central nervous system (CNS). Meissner corpuscles are important for somatosensory acuity, particularly in the digital extremities and palmar skin, and have clinical implications for peripheral and diabetic neuropathy, as well as age-related degradation of dermatological tactile sensibility