Jornal de Genética e Genomas

Human Cytomegalovirus (HCMV) is a widespread herpesvirus that infects a large portion of the human population worldwide. Despite often remaining asymptomatic in healthy individuals, it poses significant risks to immunocompromised individuals such as transplant recipients, HIV/ AIDS patients, and unborn babies when contracted during pregnancy. The emergence of drug-resistant strains of HCMV presents a growing concern in clinical management, emphasizing the importance of understanding its genetic diversity and the prevalence of resistance mutations. This article explores the genetic diversity of HCMV, methodologies for drug resistance testing, and the prevalence of resistance mutations.

Melanoma, a malignant tumor originating from melanocytes, represents a significant challenge in oncology due to its aggressive nature and propensity for metastasis. Over the years, extensive research has shed light on the molecular mechanisms underlying melanoma pathogenesis, leading to advancements in diagnosis and therapeutic interventions. This article aims to explore the latest developments in understanding melanoma's molecular basis, innovative diagnostic techniques, and promising therapeutic strategies.

Paragangliomas and pheochromocytomas are rare neuroendocrine tumors originating from the chromaffin cells of the sympathetic and parasympathetic nervous systems, respectively. While traditionally managed through surgical resection and adjuvant therapies, the advent of precision medicine has revolutionized the approach to diagnosing, treating, and managing these tumors. This article explores the evolving landscape of treatment modalities for paragangliomas and pheochromocytomas in the era of precision medicine.

In the global battle against infectious diseases, vaccines have proven to be one of the most effective tools for prevention. Traditional vaccines have typically relied on weakened or inactivated forms of pathogens to stimulate an immune response without causing illness. However, recent advances in biotechnology have paved the way for the development of novel vaccine platforms, including DNA vaccines, which hold great promise for their versatility, stability, and potential for single-dose immunization.