Jornal de AIDS e Pesquisa Clínica

When it comes to simple anatomy, the colon, rectum and anus all seem to be part of the same gastrointestinal highway, so wouldn’t the cancers that develop in these different...stretches, be the same? While colon and rectal cancers can be similar and are often referred to collectively as colorectal cancer, anal cancer is completely different in significant ways, including the cell type where cancer begins, the cause of the cancer, who gets this cancer, and how we treat it. Anal cancer is more similar to cervical cancer because the tissue that lines the anus (where anal cancer typically develops) is like the tissue that lines a woman’s cervix. Most anal cancers are related to human papillomavirus (HPV) infection like cervical cancer, and the precancerous and cancerous changes that we see in the anal canal are also similar to cervical cancer. Cervical disease and analcentric malignancy share numerous likenesses including causation by oncogenic human papillomaviruses; in any case, critical contrasts exist in their study of disease transmission, hazard factors, biologic conduct, the executives, and treatment. Albeit uncommon, the rate of anal-centric malignant growth is alarmingly high and keeps on expanding in high-hazard populaces, especially men who have intercourse with men paying little heed to their human immunodeficiency infection (HIV) status. There are no public evaluating rules for butt-centric malignancy. Utilizing the achievement of cervical malignant growth screening as a model, anal-centric disease screening approaches apply anal-centric cytology, high-goal anoscopy, and guided biopsy to direct treatment and the executives’ techniques.

Tuberculous meningitis is a subacute disease with symptoms that may persist for several weeks before diagnosis. It can clinically present similarly to other forms of meningitis and this often leads to a delay in treatment. Detection of Mycobacteria Tuberculosis in cerebral spinal fluid remains the gold standard. However, there is low positive rate of mycobacterial detection. Treatment should be initiated as soon as clinical suspicion is supported by initial CSF findings after excluding other causes such as bacteria and fungus.

Background: Tuberculosis and human immunodeficiency virus have been closely linked and East Africa is the hardest region hit by tuberculosis and Human immunodeficiency virus including Ethiopia. The main objective of this study was to identify the associated variables with tuberculosis status and CD4 cell count chance of patients jointly in Gonder teaching referral hospital, Gonder, Ethiopia implemented by SAS version 94.

Methods: A retrospective cohort study was conducted on AIDS patients whose age greater than 19 years from 1^st January, 2018- 30^th January, 2020. Generalized linear mixed model was used to identify the factors of CD4 cell count and tuberculosis status of patients separately and jointly.

Results: The mean with a standard deviation of weight, and a hemoglobin level of patients were 55.48 (10.21), and 18.25 (33.028) respectively. The baseline characteristics of patients included in this study was the median CD4 count of patients was 378 cells per cubic millimeter of blood. The generalized linear mixed model was well fitted which shows, opportunistic infection, weight and hemoglobin level were significantly associated with log of CD4 cell count and tuberculosis status of patients at 5% level of significance.

Conclusion: From this study, hemoglobin level, weight, and opportunistic infection of other disease were statistically significant at a 5% level of significance for the log of CD4 count and TB status of patients jointly. The result of the study shows that the log of CD4 count of patients increased when hemoglobin level and weight of patients increased. In addition, the log of CD4 count of AIDS patients who has other disease is 5.04 more likely to be co-infection than who has no other disease.