Jornal de relatos de casos clínicos

Tiapride Associated Toxic Epidermal Necrolysis in an HIV-Infected Patient

Abstract

Paulo Andrade, Nuno Rocha Pereira, Cândida Abreu, Paula Egipto, Daniel Moura and António Sarmento

Toxic epidermal necrolysis is a rare but severe and often fatal adverse cutaneous drug reaction. Early diagnosis and prompt discontinuation of the culprit drug is of the utmost importance, making drug causality assessment the mainstay when managing this condition. We present the first reported case of toxic epidermal necrolysis induced by tiapride, in a 43 year-old male Caucasian with a history of liver cirrhosis and HIV infection. This case report should raise awareness on the medical community to a potentially fatal reaction to a frequently prescribed drug in alcoholic patients. It also underlines the importance of further research regarding HIV infection, immune deregulation and adverse cutaneous drug reactions.