Doenças Cardiovasculares e Diagnóstico

The Relationship between ABO Blood Group and Coronary Artery Disease: A Systematic Review and Meta-Analysis

Abstract

Zhao Q, Chen X, Zhang X, Nie M, Yan Y and Zhao X

Background: The coronary artery disease (CAD) is an important risk which causes death and disability. ABO blood group is genetically transmitted through chromosome, which has some role not only in the cholesterol balance and lipid homeostasis but also inflammatory markers and thrombosis. It is supposed to have a role in developing CAD. But the relationship between CAD and ABO blood group is still controversial. Here we conducted a metaanalysis aim to evaluate the role of each blood group on CAD.

Method: We searched the related articles from PubMed and Embase which record the patients with CAD and themselves blood group. We compared the risk between each group with the others to evaluate the significance of each group to CAD.

Result: In our analysis, the O group is more frequent in coronary artery disease followed by A, B and AB group successively, which is partly different with previous meta-analysis. Compared with A blood group, O group is more subjected to CAD (OR=0.97, 95% CI=0.83 TO 1.14, p=0.73) and AB group seem to be a protective factor (OR=6.52, 95% CI=4.83 to 8.81, p<0.00001).

Conclusion: The statistical significance between A and O is unclear, but there are reasons to believe that blood group influences the incidence of CAD. O and A are served as risk factors of CAD, when AB group may be the protective factor. The subsequent mutual comparisons in B, AB and O have the similar results.