Jornal de Histologia Molecular e Fisiologia Médica

Sprague Dawley Rats' Haematotoxicity Induced by Benzeneis Mitigated by Plant Extract Loaded Silica Nanobeads

Abstract

Tousfeen Rehan

Benzene is a well-known environmental pollutant and industrial chemical that poses serious health risks, including haematotoxicity. This study investigates the potential of plant-extract-loaded silica nanobeads as a novel approach to mitigate the haematotoxic effects of benzene exposure in Sprague Dawley rats. The research delves into the pathophysiological mechanisms underlying haematotoxicity and explores the protective properties of silica nanobeads loaded with plant extracts. Findings from this study suggest a promising avenue for the development of preventive and therapeutic strategies against benzene-induced haematotoxicity. Benzene, a volatile organic compound commonly used in industrial applications and present in environmental pollution, is a recognized human carcinogen and a significant public health concern. Exposure to benzene can lead to a range of health issues, including haematotoxicity. Benzene-induced haematotoxicity is characterized by hematological disturbances such as bone marrow suppression, anemia, leukopenia, and thrombocytopenia. These adverse effects on the blood system can have severe consequences for human health.