Aurélie Pelissier- Komorek, Christian Garbar, Véronique Dalstein, Nicolas Gavillon, Olivier Graesslin and Aude-Marie Savoye
Background: Histopathologically similar to small cell carcinoma of lung, small cell neuroendocrine carcinoma of the cervix is a rare malignancy with an aggressive behavior, due to an early lymphatic involvement and hematogenous dissemination. Pelvic recurrence and distant metastasis are very common. In literature, the best treatment modality remains controversial. Cases: From a series of 3 cases and a literature review, we focus on screening, prognostic factors and treatment of this cancer. Conclusion: Human Papilloma Virus (HPV) 18 infection seems to be specifically related to small cell neuroendocrine carcinoma. Screening with HPV genotyping, and a multimodal therapy could improve the prognosis of these patients.
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