Ciência e terapia do câncer

Regulation of the Alternative NF-κb Pathway and Its Role in Cancer

Abstract

Subrahmanya D Vallabhapurapu, Koteswara Rao Pagolu and Sivakumar Vallabhapurapu

NF-κB is regulated by two distinct pathways namely the Classical NF-κB pathway and the recently discovered alternative NF-κB pathway. While the classical NF-κB pathway has been extensively studied for its role in cancer, our understanding of the regulation of the alternative NF-κB pathway and its role in cancer has been limiting. Nevertheless, significant progress has been made recently that revolves around the regulation of NF-κB inducing kinase and its role in cancer. These recent developments will be discussed in this editorial.