Elaine Regina Delicato de Almeida, Andréa Name Colado Simão, HelenaKaminamiMorimoto, Ana Paula Kallaur, Tamires Flauzino, Daniela Frizon Alfieri, Jair Aparecido de Oliveira, LuisToshio Ueda, Marcel Alysson Batisti Lozovoy, Isaias Dichi, Maria AngelicaEhara Watanabe and Edna Maria Vissoci Reiche
Objective: The aim of this study was to evaluate the association between the PvuII polymorphism in the intron 15 of low-density lipoprotein receptor (LDLR) and dyslipidemia in human immunodeficiency type 1 (HIV-1)-infected individuals. Methods: The study included 355 HIV-1-infected patients [100 antiretroviral-naïve and 255 on highly active antiretroviral therapy (HAART)]. The PvuIILDLR polymorphism was determined using PCR-RFLP methods and the lipid profile was evaluated by serum levels of total cholesterol (COL), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Results: Those patients on HAART showed higher COL, TG, and LDL-C levels than those HAART-naïve (207.0 vs. 175.0 mg/dL, p<0.0001; 167.0 vs. 119.5 mg/dL, p<0.0001, and 124.2 vs. 102.9 mg/dL, p=0.0003, respectively). The frequency of patients with increased levels of COL, TG, and LDL-C was higher among those on HAART than HAARTnaïve (86.6% vs.67.4%, p<0.0001; 80.9% vs. 69.7%, p=0.0380, and 74.4% vs. 62.6%, p=0.0339, respectively). The frequency of the PvuIILDLR genotypes did not differ among the patients according to COL, TG, and LDL-C levels (p>0.05). However, the frequency of high HDL-C levels was higher among those patients carrying the P2P2 genotype (11.8% vs. 5.6%, p=0.0398). Conclusions: The results underscored that HAART are associated with dyslipidemia in some HIV-1-infected patients but not in all of them. Moreover, the results suggest that the P2P2 genotype of the PvuIILDLR polymorphism might be in part modulating the effect of HAART and HIV-1 infectionin HDL-Clevels an
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