Jose Russo
The genomic profile of parous women has shown that genes which are activated only within the first five years after pregnancy, may contribute to the increased risk of breast cancer in certain women. At the same time, pregnancy’s protective effect is induced by a long-lasting genomic signature. This signature reveals that the differentiation process is centered around chromatin remodeling and represents a safeguard mechanism at genomic and post-transcriptional levels that maintains the fidelity of the transcription process, which could be the ultimate step mediating the protection of the breast conferred by full term pregnancy.
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