Jornal de AIDS e Pesquisa Clínica

Pharmacokinetics and Pharmacodynamics of Novel Nucleoside Reverse Transcriptase Inhibitors

Abstract

Josefa Antonia

Nucleoside reverse transcriptase inhibitors (NRTIs) are cornerstone antiretroviral drugs used in the treatment of HIV/AIDS. The advent of novel NRTIs has expanded therapeutic options, offering improved efficacy and safety profiles. This article explores the pharmacokinetics and pharmacodynamics of these novel NRTIs, emphasizing their absorption, distribution, metabolism and excretion (ADME) properties, as well as their mechanisms of action, resistance profiles and clinical implications.